Table 3.

Macroscopic findings and histological variables related to the main neuropathological diagnoses (Alzheimer’s disease, vascular dementia, and Lewy body disease) and additional combined pathologies (LATE, AGD, and ARTAG) in the VARSpath cohort.

Macroscopic Findings
Brain weight (g.); mean (SD 1)	966 (137)
Global atrophy (0–3); median (IQR 2)	2 (2, 3)
Ventricular dilatation (0–3); median (IQR)	2 (2, 2)
Atrophy of the medial temporal lobe; median (IQR)	3 (2, 3)
Neuropathological Variables
Main Neuropathological diagnosis; %	79.6 (Alzheimer’s disease) 10.2 (Vascular dementia) 6 (Lewy body dementia) 4.2 (Others)
Thal stage; % (0/1/2/3/4/5)	0.6/1.8/0.6/6.1/28/62.8
NIA A; % (0/1/2/3)	0.6/2.4/6.1/90.9
Braak tau; % (0/1/2/3/4/5/6)	1.8/5.5/6.1/7.3/38.2/41.2
NIA B; % (0/1/2/3)	0/7.3/13.3/79.4
NIA C; % (0/1/2/3)	7.2/9/15.1/68.7
ADNC; % (0/1/2/3)	2.4/6.7/13.9/77.0
Braak α-syn; % (0/1/2/3/4/5/6)	59.9/0.6/11.4/6.6/10.2/11.4
LPC; % (NP/OB/AM/BS/LI/NC)	42.5/13.7/18.3/2.6/10.5/12.4
Total vascular score; median (IQR)	8 (5, 11)
VCING score; % (low/intermediate/high)	61.1/26.9/7.8
CAA intensity (0–4); median (IQR)	2 (1, 3)
HS stage; % (0/1/2/3/4)	29.9/8.9/15.3/14.6/31.2
LATE; % (0/1/2/3)	29.3/9.8/56.1/4.9
TDP43 stage (Josephs et al. [31]); % (0/1/2/3/4/5/6)	29.3/8.5/15.9/16.5/21.3/3.7/4.9
AGD; %	12
ARTAG; %	53

¹ Standard Deviation; ² Interquartile Range. ADNC: Alzheimer’s disease neuropathological change; AGD: argyrophilic grain disease; ARTAG: aging-related tau astrogliopathy; Braak α-syn: Braak α-synuclein stage; CAA intensity: cerebral amyloid angiopathy intensity; HS stage: hippocampal sclerosis stage; LATE: limbic predominant age-related TDP-43 encephalopathy stage; LPC: Lewy pathology consensus type; NP: no LBP; OB: LBP limited to the olfactory bulb; AM: amygdala-predominant LBP; BS: brainstem-predominant LBP; LI: limbic LBP; NC: neocortical LBP; VCING score: vascular cognitive impairment neuropathology guidelines score.