Table 4.
Comparison of key variables between main neuropathological diagnoses (Alzheimer’s disease, vascular dementia, and Lewy body dementia).
| Sociodemographic, Genetic, and Clinical Data | ||||
|---|---|---|---|---|
| AD | VD | LBD | p | |
| n | 133 | 17 | 10 | |
| Sex; % (females) | 81.9 | 64.7 | 60 | NS |
| Age at onset, yrs.; mean (SD 1) | 75.1 (7.4) | 77.9(4.8) | 76.5 (6.4) | NS |
| Age at death, yrs.; mean (SD) | 87.3 (6.6) | 87.3 (4.9) | 88.7 (6.7) | NS |
| Disease duration, yrs.; mean (SD) | 12.3 (4.3) | 9.1 (4) | 12.9 (4.9) | NS |
| Time in nursing home, mths.; mean (SD) | 56.4 (37.8) | 25.3 (31.4) | 56.5 (41.6) | <0.05 |
| ApoE4 (at least one allele); % | 54.5 | 23.5 | 14.3 | <0.01 |
| Neuropathological Variables | ||||
| Braak tau (0–6); median (IQR 2) | 6 (5, 6) | 3 (2, 4) | 3.5 (2.75, 4) | <0.001 |
| ADNC (0–3); median (IQR) | 3 (3, 3) | 1 (1, 2) | 2 (1, 2) | <0.001 |
| Braak α-syn (0–6); median (IQR) | 0 (0, 4) | 0 (0, 0) | 6 (5, 6) | <0.001 |
| Total vascular score (0–20); median (IQR) | 8 (5, 10) | 11 (9, 13) | 6.5 (4.25, 11.25) | =0.001 |
| CAA intensity (0–4); median (IQR) | 2 (1, 3) | 1 (1, 2) | 2 (1, 2) | =0.055 |
| HS stage (0–4); median (IQR) | 3 (0.5, 4) | 0 (0, 2.5) | 0 (0, 2) | =0.01 |
| LATE (0–3); median (IQR) | 2 (0, 2) | 0 (0, 2) | 1.5 (0, 2) | NS |
| AGD; % | 7.5 | 41.2 | 20 | =0.001 |
| ARTAG; % | 54.9 | 41.2 | 50 | NS |
1 Standard Deviation; 2 Interquartile Range. ADNC: Alzheimer’s disease neuropathological change; AGD: argyrophilic grain disease; ARTAG: aging-related tau astrogliopathy; Braak α-syn: Braak α-synuclein stage; CAA intensity: cerebral amyloid angiopathy intensity; HS stage: hippocampal sclerosis stage; LATE: limbic-predominant age-related TDP-43 encephalopathy stage.