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. 2024 Nov 13;25(22):12175. doi: 10.3390/ijms252212175

Figure 3.

Figure 3

The effect of Mitomycin C on cell viability and ROS production is abrogated by antioxidants. The cells were either pretreated for 1 h with or without 25 µM imipramine prior to stimulation for 48 h either with or without 0.3 µM mitomycin C (MMC) (A). The data of cell counts are expressed as % of control and are means ± SD (n = 3). *** p < 0.0001, ** p < 0.001, and * p < 0.05 indicate statistical significance when compared to the control group. (B) The cells were incubated for 48 h either with or without 0.3 µM MMC C. The data are expressed in % of the untreated control and are means ± SD of at least three (n = 3) independent experiments. (C) The cells were treated for 48 h with either 0.3 µM MMC C (MMC), 3 mM N-acetyl-Cysteine (NAC), 100 µM Tiron, or combined. The results are expressed as % of control and are means ± SD (n = 3). *** p < 0.0001, ** p < 0.001, and * p < 0.05 are significantly different when compared to the control group.