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Hypothalamic–pituitary–adrenal (HPA) axis components and regulations. The delivery of corticotropin releasing hormone (CRH) by the hypothalamus to the pituitary gland induces the secretion of adrenocorticotropic hormone (ACTH). ACTH leads to the adrenal glands producing cortisol and aldosterone, which mediates negative feedback to the hypothalamus through the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).
