Table 2.
Demographic characteristics and disease distributions of monoclonal gammopathies in each immunoglobulin isotype.
| Disease Categorization | n = 863 | Type (κ/λ) | Sex (M/F) | Age (Years) | MP Level (g/dL) | |
|---|---|---|---|---|---|---|
| IgG | Total | 559 (100.0) | 337/222 | 319/240 | 71 (31–94) | 2.59 (0.03–9.45) |
| Multiple myeloma * | 369 (66.0) | 228/141 | 190/179 | 70 (37–93) | 3.70 (0.13–9.45) | |
| Solitary plasmacytoma | 13 (2.3) | 7/6 | 9/4 | 60 (46–76) | 0.95 (0.19–2.31) | |
| Amyloidosis | 6 (1.1) | 3/3 | 4/2 | 71 (31–76) | 1.46 (0.90–2.90) | |
| Mature lymphoid neoplasm | 3 (0.5) | 3/0 | 2/1 | 59 (58–68) | 1.05 (0.09–1.09) | |
| LPM, unspecified | 4 (0.7) | 1/3 | 3/1 | 79 (49–82) | 5.30 (3.24–8.17) | |
| MGCS | 12 (2.2) | 3/9 | 11/1 | 71.5 (62–85) | 0.86 (0.20–2.35) | |
| MGUS | 152 (27.2) | 92/60 | 100/52 | 73 (32–94) | 0.73 (0.03–2.93) | |
| IgA | Total | 165 (100.0) | 95/70 | 90/75 | 70 (47–86) | 2.74 (0.01–8.84) |
| Multiple myeloma * | 126 (76.4) | 78/48 | 66/60 | 70 (49–86) | 3.49 (0.24–8.84) | |
| Amyloidosis | 4 (2.4) | 1/3 | 2/2 | 74.5 (66–78) | 1.18 (0.11–1.43) | |
| LPM, unspecified | 1 (0.6) | 0/1 | 0/1 | 76 (76–76) | 4.35 (4.35–4.35) | |
| MGCS | 1 (0.6) | 1/0 | 1/0 | 57 (57–57) | 1.43 (1.43–1.43) | |
| MGUS | 33 (20.0) | 15/18 | 21/12 | 69 (47–85) | 0.71 (0.01–1.42) | |
| IgM | Total | 68 (100.0) | 56/12 | 50/18 | 71.5 (42–90) | 1.20 (0.02–6.67) |
| Multiple myeloma * | 2 (2.9) | 2/0 | 2/0 | 70.5 (64–77) | 3.84 (1.07–6.60) | |
| WM | 41 (60.3) | 38/3 | 33/8 | 70 (42–88) | 2.26 (0.57–6.67) | |
| Amyloidosis | 1 (1.5) | 1/0 | 1/0 | 85 (85–85) | 0.41 (0.41–0.41) | |
| Mature lymphoid neoplasm | 4 (5.9) | 4/0 | 1/3 | 70 (64–75) | 0.76 (0.40–5.80) | |
| LPM, unspecified | 1 (1.5) | 0/1 | 1/0 | 83 (83–83) | 4.58 (4.58–4.58) | |
| MGCS | 2 (2.9) | 1/1 | 1/1 | 75 (74–76) | 0.34 (0.30–0.38) | |
| MGUS | 17 (25.0) | 10/7 | 11/6 | 72 (58–90) | 0.29 (0.02–1.26) | |
| FLC | Total | 71 (100.0) | 19/52 | 43/28 | 68 (33–89) | 0.40 (0.02–6.54) |
| Multiple myeloma * | 63 (88.7) | 14/49 | 36/27 | 70 (33–89) | 0.43 (0.03–6.54) | |
| Solitary plasmacytoma | 1 (1.4) | 1/0 | 0/1 | 57 (57–57) | 0.20 (0.20–0.20) | |
| MGUS | 7 (9.9) | 4/3 | 7/0 | 65 (50–82) | 0.27 (0.02–0.88) |
Data are n (%), n/n, or median (range) values. * Smouldering multiple myeloma and plasma cell leukemia were included. Abbreviations: MP, monoclonal protein; LPM, lymphoplasmacytic malignancy; MGCS, monoclonal gammopathy of clinical significance; MGUS, monoclonal gammopathy of undetermined significance; WM, Waldenström’s macroglobulinemia; FLC, free light chain.