Table 4.
Factors associated with lymphoplasmacytic malignancies in multivariate logistic regression analysis (n = 640) *.
| Characteristic | Univariate Analyses | Multivariate Analyses | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | |
| Sex (reference: male) | 1.87 | 1.26–2.80 | 0.002 | 2.08 | 1.18–3.75 | 0.013 |
| Age (years) | 0.98 | 0.96–1.00 | 0.025 | 0.95 | 0.92–0.98 | 0.001 |
| Serum MP level (g/dL) | 3.07 | 2.47–3.91 | <0.001 | 3.53 | 2.42–5.31 | <0.001 |
| Abnormal FLC ratio | 12.3 | 7.81–19.50 | <0.001 | 6.15 | 3.44–11.24 | <0.001 |
| WBC (×103/μL) | 0.94 | 0.90–0.99 | 0.015 | 0.50 | 0.23–1.16 | 0.104 |
| Hemoglobin (g/dL) | 0.73 | 0.67–0.79 | <0.001 | 0.82 | 0.71–0.94 | 0.005 |
| RDW (%) | 1.31 | 1.18–1.47 | <0.001 | |||
| Platelet (×103/μL) | 0.82 | 0.67–0.99 | 0.038 | |||
| Lymphocyte (×103/μL) | 1.29 | 1.03–1.67 | 0.045 | 2.53 | 0.90–7.09 | 0.080 |
| Monocyte (×103/μL) | 0.79 | 0.51–1.25 | 0.3 | |||
| Neutrophil (×103/μL) | 0.90 | 0.84–0.96 | 0.004 | 2.06 | 0.86–4.80 | 0.104 |
| Total protein (g/dL) | 2.02 | 1.76–2.35 | <0.001 | 0.80 | 0.59–1.09 | 0.148 |
| Albumin (g/dL) | 0.64 | 0.48–0.85 | 0.002 | |||
| Creatinine (mg/dL) | 0.98 | 0.87–1.11 | 0.7 | |||
| Total calcium (mg/dL) | 1.59 | 1.27–2.02 | <0.001 | 1.81 | 1.26–2.73 | 0.003 |
| ß2-microglobulin (μg/L) | 1.06 | 1.02–1.11 | 0.003 | 1.04 | 1.00–1.09 | 0.095 |
| LDH (U/L) | 0.93 | 0.85–1.02 | 0.12 | |||
| Hypertension | 0.68 | 0.47–1.00 | 0.051 | |||
| Diabetes mellitus | 0.65 | 0.43–0.99 | 0.04 | |||
* Lymphoplasmacytic malignancies (n = 503), monoclonal gammopathy of undetermined significance (n = 137). Abbreviations: MP, monoclonal protein; LDH, lactate dehydrogenase; WBC, white blood cell; RDW, red cell distribution width; FLC, free light chain; OR, odds ratio; CI, confidence interval.