Table 1.
Distribution of Variables in the ACTT Risk Profile Among ACTT-1 Participants vs. ACTT-2 Participants
| Covariate | Least Risk | Lower Risk | Moderate Risk | High Risk | Overall | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
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| ACTT-1 | ACTT-2 | ACTT-1 | ACTT-2 | ACTT-1 | ACTT-2 | ACTT-1 | ACTT-2 | ACTT-1 | ACTT-2 | |
| (n = 242) | (n = 271) | (n = 277) | (n = 236) | (n = 291) | (n = 221) | (n = 241) | (n = 271) | (n = 1051) | (n = 999) | |
|
| ||||||||||
| Median baseline ALC (IQR), × 109 cells/L | 1.4 (1.1–1.8) | 1.5 (1.2–1.9) | 1.1 (0.9–1.4) | 1.1 (0.9–1.3) | 0.9 (0.7–1.1) | 0.9 (0.7–1.2) | 0.6 (0.4–0.8) | 0.7 (0.5–0.9) | 1.0 (0.7–1.3) | 1.0 (0.7–1.4) |
| Median baseline ANC (IQR), × 109 cells/L | 3.4 (2.3–4.7) | 3.3 (2.3–4.4) | 4.6 (3.4–5.9) | 4.3 (3.4–5.7) | 5.7 (4.1–7.9) | 5.9 (4.5–7.4) | 8.1 (5.9–10.7) | 7.8 (5.8–11.0) | 5.1 (3.5–7.5) | 5.1 (3.6–7.2) |
| Median baseline platelet count (IQR), × 109 cells/L | 256 (195–354) | 251 (182–314) | 228 (172–284) | 222 (172–284) | 215 (159–276) | 204 (168–262) | 192 (151–251) | 207 (159–257) | 220 (167–287) | 218 (170–279) |
| Baseline ordinal score, n (%)* 4 (hospitalized, not requiring supplemental oxygen, requiring ongoing medical care) |
38 (16) | 52 (19) | 44 (16) | 39 (17) | 34 (12) | 22 (10) | 22 (9) | 24 (9) | 138 (13) | 137 (14) |
| 5 (hospitalized, requiring supplemental oxygen) | 120 (50) | 172 (63) | 115 (42) | 129 (55) | 105 (36) | 106 (48) | 95 (39) | 138 (51) | 435 (41) | 545 (55) |
| 6 (hospitalized, receiving noninvasive ventilation or high-flow oxygen devices) | 37 (15) | 38 (14) | 49 (18) | 47 (20) | 64 (22) | 62 (28) | 43 (18) | 65 (24) | 193 (18) | 212 (21) |
| 7 (hospitalized, receiving invasive mechanical ventilation or ECMO) | 47 (19) | 39 (3) | 69 (25) | 21 (9) | 88 (30) | 31 (14) | 81 (34) | 44 (16) | 285 (27) | 105 (11) |
ACTT = Adaptive COVID-19 Treatment Trial; ALC = absolute lymphocyte count; ANC = absolute neutrophil count; ECMO = extracorporeal membrane oxygenation.
*
Values are column percentages with the given baseline ordinal score value among participants in the specified risk quartile and stage.