Table 1.
List of proteins specifically modulated in the ΔppoA or ΔppoC mutants when compared with the wild type in the presence of caspofungin (CSP).
| Protein | ΔppoA/WT (CSP) * |
|---|---|
| AFUA_5G09580 (hydrophobin) | 5.7621 |
| AFUA_1G13670 (related to sporozoite surface protein 2) | 3.3037 |
| AFUA_7G01430 (NopA, Opsin) | 3.9007 |
| AFUA_1G02800 (chitinase) | 1.5652 |
| AFUA_6G08470 (glycerol kinase) | 1.982 |
| AFUA_1G05580 (glycogenin) | 1.572 |
| AFUA_8G02060 (N-acetylglucosaminylphosphatidylinositol deacetylase) | 1.0966 |
| AFUA_6G09930 (AP-1-like transcription factor yap1) | 1.0689 |
| AFUA_2G05730 (MFS siderochrome iron transporter C) | 1.0328 |
| AFUA_6G07270 (long-chain fatty acid transporter) | 1.0156 |
| AFUA_2G02520 (Cell polarity protein Tea1) | −1.3091 |
| AFUA_6G10480 (Peptidyl-prolyl cis-trans isomerase-like 3) | −1.9383 |
| AFUA_4G06330 (C6 transcription factor) | −12.169 |
| Protein | ΔppoC/WT (CSP) * |
| AFUA_4G10130 (alpha-amylase) | 12.271 |
| AFUA_1G09540 (vacuolar transporter chaperon Vtc1) | 11.797 |
| AFUA_7G06750 (phosphoglycerate mutase) | 9.2397 |
| AFUA_7G04020 (lipase) | 8.2124 |
| AFUA_8G05360 (FAS1 domain-containing protein) | 8.0016 |
| AFUA_5G09130 (polysaccharide deacetylase) | 7.1757 |
| AFUA_1G12040 (chitin synthase export chaperone) | 6.4859 |
| AFUA_8G00230 (verruculogen synthase) | 4.8539 |
| AFUA_2G17580 (scytalone dehydratase arp1) | 4.2638 |
| AFUA_2G17530 (laccase abr2) | 4.2588 |
| AFUA_1G16410 (C6 transcription factor) | 2.3637 |
| AFUA_1G11000 (C6 transcription factor) | 2.1857 |
| AFUA_2G17560 (hydroxynaphthalene reductase arp2) | 1.4489 |
| AFUA_6G00750 (pyruvate decarboxylase) | 1.4218 |
| AFUA_5G12550 (N-acetylglucosaminylphosphatidylinositol deacetylase) | 1.3624 |
| AFUA_6G01840 (C6 transcription factor) | 1.3588 |
| AFUA_5G05600 (forkhead transcription factor Sep1) | 1.3116 |
| AFUA_1G17080 (glucosamine 6-phosphate N-acetyltransferase) | 1.2597 |
| AFUA_3G08820 (glycosyl hydrolase) | 1.0264 |
| AFUA_3G01530 (Phosphatidylglycerol specific phospholipase) | 1.3353 |
| AFUA_3G09950 (phospholipid:diacylglycerol acyltransferase) | 1.2213 |
| AFUA_6G07570 (palmitoyltransferase swf1) | 1.213 |
| AFUA_4G04200 (myo-inositol-1(Or 4)-monophosphatase) | 1.1101 |
| AFUA_1G09670 (HLH transcription factor GlcD gamma) | 1.0999 |
| AFUA_5G09070 (glycosyltransferase family 8 protein) | 1.0634 |
| AFUA_2G11860 (lipoprotein) | 1.0475 |
| AFUA_4G12180 (C6 transcription factor Prf) | −1.076 |
| AFUA_2G04210 (L-tyrosine degradation gene cluster protein hmgX) | −1.2644 |
| AFUA_3G00370 (phosphoketolase) | −1.4249 |
| AFUA_1G09940 (casein kinase II beta 2 subunit) | −2.112 |
| AFUA_7G08350 (alpha-1,3-glucanase) | −2.4887 |
| AFUA_7G04800 (G-protein coupled receptor GprC) | −5.5981 |
| AFUA_4G06940 (sphingolipid 4-desaturase) | −9.4216 |
* Differentially expressed proteins were defined as those with a minimum two-fold change in protein abundance (log2FC ≥ 1.0 and ≤−1.0; FDR of 0.05) when compared to the wild-type strain in the presence of CAS.