Table 3.
Univariate and multivariate Cox proportional hazards model results for progression.
| Progression | ||||||
|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | |||||
| p-Value | Hazard Ratio | %95 CI | p-Value | Hazard Ratio | %95 CI | |
| Age at diagnosis | 0.029 * | 1.023 | 1.002–1.043 | 0.261 | 1.013 | 0.990–1.036 |
| Age of Onset of Lesions (Years) | 0.214 | 1.012 | 0.993–1.031 | - | - | - |
| Time from Appearance to Diagnosis (Months) | 0.064 | 1.003 | 1.000–1.005 | - | - | - |
| Gender (Male) | 0.715 | 1.111 | 0.630–1.962 | - | - | - |
| Patch/Patch + Plaque (Patch + Plaque) | 0.958 | 1.015 | 0.580–1.777 | - | - | - |
| Morphological Findings | ||||||
| Hyperpigmentation (Yes) | 0.092 | 0.522 | 0.245–1.112 | - | - | - |
| Erythema (Yes) | 0.787 | 1.079 | 0.620–1.878 | - | - | - |
| Pruritus (Yes) | 0.035 * | 1.906 | 1.046–3.473 | 0.153 | 1.624 | 0.835–3.155 |
| Histopathological Findings | ||||||
| Classic (Yes) | 0.015 * | 0.498 | 0.051–0.873 | 0.022 * | 0.477 | 0.258–0.901 |
| Folliculotropism (Yes) | 0.085 | 2.502 | 0.882–7.096 | - | - | - |
| CD8 (+) (Yes) | 0.920 | 0.960 | 0.431–2.139 | - | - | - |
| Stage at Diagnosis | ||||||
| IB | 0.890 | 0.957 | 0.516–1.776 | - | - | - |
| IIA | 0.667 | 0.856 | 0.421–1.740 | - | - | - |
| T Stage at Diagnosis (T2) |
0.319 | 0.756 | 0.437–1.310 | - | - | - |
| N Stage at Diagnosis | ||||||
| Nx | 0.009 * | 2.404 | 1.250–4.623 | 0.905 | 0.951 | 0.417–5.555 |
| N1 | 0.272 | 1.520 | 0.720–3.210 | - | - | - |
| β-2 Microglobulin (High) | 0.238 | 1.388 | 0.805–2.391 | - | - | - |
| LDH (High) | 0.038 * | 2.107 | 1.041–4.267 | 0.004 * | 3.424 | 1.475–7.947 |
| Eosinophilia (Yes) | 0.112 | 2.350 | 0.820–6.735 | - | - | - |
| Initial Treatment Type | ||||||
| Skin-directed | 0.005 * | 0.415 | 0.210–0.770 | 0.581 | 0.809 | 0.382–1.716 |
| Combined | 0.170 | 1.615 | 0.814–3.205 | - | - | - |
| Initial Treatment | ||||||
| NB-UVB | 0.096 | 1.694 | 0.911–3.149 | - | - | - |
| PUVA | 0.022 * | 0.524 | 0.112–0.911 | 0.313 | 0.722 | 0.384–1.359 |
| PUVA + IFN | 0.757 | 1.146 | 0.484–2.710 | - | - | - |
* p < 0.05 significant relationship. p > 0.05 no significant relationship; CI: confidence interval; LDH: lactate dehydrogenase; NB-UVB: Narrowband Ultraviolet B; PUVA: Psoralen + Ultraviolet A; IFN: Interferon.