Table 4.
Univariate and multivariate Cox proportional hazards model results for complete response.
| Complete Response | ||||||
|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | |||||
| p-Value | Hazard Ratio | %95 CI | p-Value | Hazard Ratio | %95 CI | |
| Age at Diagnosis | 0.043 * | 1.014 | 1.001–1.028 | 0.065 | 1.015 | 0.999–1.030 |
| Age of Onset of Lesions (Years) | 0.140 | 1.010 | 0.997–1.022 | - | - | - |
| Time to Diagnosis (Months) | 0.314 | 1.001 | 0.999–1.003 | - | - | - |
| Gender (Male) | 0.030 * | 0.660 | 0.250–0.960 | 0.028 * | 0.638 | 0.150–0.952 |
| Patch/Patch + Plaque (Patch + Plaque) | 0.056 | 0.696 | 0.480–1.009 | - | - | - |
| Morphological Findings | ||||||
| Hyperpigmentation (Yes) | 0.377 | 0.815 | 0.519–1.282 | - | - | - |
| Erythema (Yes) | 0.069 | 1.444 | 0.972–2.145 | - | - | - |
| Pruritus (Yes) | 0.369 | 1.191 | 0.813–1.743 | - | - | - |
| Histopathological Findings | ||||||
| Classic (Yes) | 0.770 | 1.062 | 0.708–1.593 | - | - | - |
| Folliculotropism (Yes) | 0.870 | 1.078 | 0.437–2.659 | - | - | - |
| CD8 (+) (Yes) | 0.360 | 1.254 | 0.772–2.037 | - | - | - |
| Stage at Diagnosis | ||||||
| IB | 0.718 | 0.930 | 0.627–1.380 | 0.813 | 1.050 | 0.703–1.567 |
| IIA | 0.003 * | 0.402 | 0.192–0.737 | 0.863 | 1.194 | 0.159–8.960 |
| T Stage at Diagnosis (T2) |
0.552 | 0.894 | 0.618–1.294 | - | - | - |
| N Stage at Diagnosis | ||||||
| Nx | 0.059 | 0.382 | 0.141–1.039 | - | - | - |
| N1 | 0.680 | 0.809 | 0.296–2.214 | - | - | - |
| β-2 Microglobulin (High) | 0.003 * | 0.535 | 0.110–0.812 | 0.012 * | 0.567 | 0.254–0.883 |
| LDH (High) | 0.059 | 0.382 | 0.141–1.039 | - | - | - |
| Eosinophilia (Yes) | 0.680 | 0.809 | 0.296–2.213 | - | - | - |
| Initial Treatment Type | ||||||
| Skin-directed | 0.571 | 1.155 | 0.702–1.900 | - | - | - |
| Combined | 0.850 | 0.952 | 0.573–1.583 | - | - | - |
| Initial Treatment | ||||||
| NB-UVB | 0.001 * | 0.538 | 0.250–0.785 | 0.769 | 0.922 | 0.536–1.587 |
| PUVA | 0.001 * | 1.990 | 1.338–2.961 | 0.018 * | 1.870 | 1.114–3.139 |
| PUVA + IFN | 0.118 | 5.114 | 0.663–39.463 | - | - | - |
* p < 0.05 significant relationship. p > 0.05 no significant relationship; CI: confidence interval; LDH: lactate dehydrogenase; NB-UVB: Narrowband Ultraviolet B; PUVA: Psoralen + Ultraviolet A; IFN: Interferon.