Table 1.
New nitrogen-containing metabolites (1–97) isolated from Fusarium fungi and their biological activities.
| Metabolite Class |
Metabolite Name | Biological Activity |
Fusarium Species |
Fungal Origin |
Ref. |
|---|---|---|---|---|---|
| Amines | |||||
| 2-Amino-14,16-dimethyloctadecan-3-ol (1) | Cytotoxic activity | F. avenaceum | Plant pathogenic fungus | [24] | |
| Deacetyl fusarochromene (2); 4′-O-acetyl fusarochromanone (3) | Antimalarial activity | Fusarium sp. | Entomogenous fungus | [25] | |
| Deacetamidofusarochrom-2′,3′-diene (4) | Cytotoxic and antibacterial activities | F. equiseti | Marine-derived fungus | [26] | |
| Amides | |||||
| Decalintertracids A (5/6) and B (7/8) | Phytotoxic activity | F. equiseti | Plant endophytic fungus | [27] | |
| (3E,7E)-11,12-Dihydroxy-4,8,12-trimethyltrideca-3,7-dienamide (9) | - | Fusarium sp. | Plant endophytic fungus | [28] | |
| (S,E)-Methyl-2-(2,4-dimethylhex-2-enamido)acetate (10) | - | F. oxysporum | Plant endophytic fungus | [29] | |
| DihydroNG393 (11); dihydrolucilactaene (12); 13α-hydroxylucilactaene (13) | Antimalarial activity | Fusarium sp. | Plant endophytic fungus | [30] | |
| Fusaindoterpene A (14) | - | Fusarium sp. | Marine-derived fungus | [31] | |
| Fusaramin (15) | Antibacterial and antimitochondrial activities | Fusarium sp. | Soil-derived fungus | [32] | |
| Fusarin L (16) | Anti-inflammatory activity | F. solani | Marine-derived fungus | [33] | |
| Furarin X1 (17) | Cytotoxic activity | F. graminearum | Plant pathogenic fungus | [34] | |
| Fusarisetin B (18) | Cytotoxic activity | F. equiseti | Entomogenous fungus | [35] | |
| Fusarisetins C (19) and D (20) | - | F. equiseti | Marine-derived fungus | [36] | |
| Fusaribenzamide A (21) | Antifungal activity | Fusarium sp. | Plant endophytic fungus | [37] | |
| Fusarochromene (22) | - | F. sacchari | Plant pathogenic fungus | [38] | |
| Kaneoheoic acid G (23) | Antibacterial activity | F. graminearum | Marine-derived fungus | [39] | |
| 8(Z)-Lucilactaene (24); 4(Z)-lucilactaene (25) | Anti-inflammatory activity | Fusarium sp. | Plant endophytic fungus | [40] | |
| N-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}acetyl)glycine (26); methyl N-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}acetyl)glycinate (27) | - | Fusarium sp. | Marine-derived fungus | [41] | |
| Prelucilactaenes G (28) and H (29) | Antimalarial activity | Fusarium sp. | Plant endophytic fungus | [42] | |
| Proliferatins A–C (30–32) | Anti-inflammatory activity | F. proliferatum | Fungal stroma-derived fungus | [43] | |
| Pyrrolidinone analogs 33, 34, and 35 | - | F. decemcellulare | Plant endophytic fungus | [44] | |
| Cyclic peptides | |||||
| Acuminatums E (36) and F (37) | Antifungal activity | F. lateritium | Plant endophytic fungus | [45] | |
| Amoenamide C (38); sclerotiamide B (39) | Antimicrobial and larvicidal activities | F. sambucinum | Plant endophytic fungus | [46] | |
| Apicidin L (40) | Cytotoxic and antimalarial activities | F. fujikuroi | Plant pathogenic fungus | [47] | |
| Beauvervin H (41) | Cytotoxic activity | Fusarium sp. | Plant endophytic fungus | [48] | |
| Beauvericins M (42) and N (43) | - | Fusarium sp. | Plant endophytic fungus | [49] | |
| Cyclo-(L-Trp-L-Phe-L-Phe) (44) | Cytotoxic and antibacterial activities | F. proliferatum | Plant endophytic fungus | [50] | |
| Enniatin W (45) | Cytotoxic activity | F. oxysporum | Plant endophytic fungus | [51] | |
| Fusahexin (46) | - | F. graminearum | Plant pathogenic fungus | [52] | |
| Fusaristatins D–F (47–49) | - | Fusarium sp. | Plant endophytic fungus | [53] | |
| Gramipiperazines A (50) and B (51) | Antibacterial activity | F. graminearum | Marine-derived fungus | [39] | |
| Pyridines | |||||
| Climacomontaninate D (52) | - | Fusarium sp. | Entomogenous fungus | [54] | |
| Fusaricates H–K (53–56) | - | F. solani | Mangrove-derived fungus | [55] | |
| Fasaripyridines A (57) and B (58) | Antimicrobial and cytotoxic activities | Fusarium sp. | Marine-derived fungus | [56] | |
| Pyridones | |||||
| Fusapyridons C (59) and D (60) | Cytotoxic activity | F. avenaceum | Entomopathogenic fungus | [57] | |
| Fusarone A (61) | Cytotoxic and antibacterial activities | F. proliferatum | Plant endophytic fungus | [50] | |
| 1′-Methoxy-6′-epi-oxysporidinone (62) | - | F. concentricum | Plant endophytic fungus | [58] | |
| Indole analogs | |||||
| Chlamydosporin (63) | Phytotoxic activity | F. chlamydosporum | Plant endophytic fungus | [59] | |
| Ethyl 3-indoleacetate (64) | Cytotoxic and antibacterial activities | F. proliferatum | Plant endophytic fungus | [50] | |
| Fusaconate A (65) | - | F. concentricum | Plant endophytic fungus | [58] | |
| Fusarindoles A–E (66–70) | - | F. equiseti | Marine-derived fungus | [60] | |
| (+)-Fusaspoid A (71); (−)-fusaspoid A (72) | - | Fusarium sp. | Marine-derived fungus | [61] | |
| Fusaindoterpene B (73); fusarindoles A–C (74–76); isoalternatine A (77) | Inhibitory activity against Zika virus | Fusarium sp. | Marine-derived fungus | [31] | |
| Imidazole analogs | |||||
| Fusaritricines A–I (78–86) | Antibacterial activity | F. tricinctum | Plant endophytic fungus | [62] | |
| (+)-Fusaritricine J (87), (−)-fusaritricine J (88), and fusaritricines K–P (89–94) | Antibacterial activity | F. tricinctum | Plant endophytic fungus | [63] | |
| Others | |||||
| Fusaravenin (95) | - | F. avenaceum | Soil-derived fungus | [64] | |
| Fusaroxazin (96) | Cytotoxic and antimicrobial activities | F. oxysporum | Plant endophytic fungus | [65] | |
| Secobeauvericin A (97) | - | Fusarium sp. | Plant endophytic fungus | [49] | |