Table 2.

Main advantages and disadvantages of the most common materials used in microfluidic devices and biomodels [42,43,44,45,46].

	Main Advantages	Main Disadvantages
PDMS	Simple and low-cost fabrication, gas permeability, biocompatibility, optical transparency, variable elasticity, cell culture, easy fabrication (soft lithography).	Can absorb hydrophobic molecules, hydrophobic nature (can be modified), swelling in organic solvents.
PMMA	Low-cost fabrication compared to glass and silicon, optical transparency.	Rigid, thermal degradation and thermal oxidative degradation in the presence of oxygen, permeability inability, can deform under high pressure.
3D printing resins	Simple and low-cost fabrication, variable mechanical properties, ability to create complex geometries.	Inadequate optical transparency, low gas permeability, surface roughness, limited material choices depending on printer technology.
Glass	Optical transparency, inert, excellent roughness, and chemical resistance.	Rigid, fragile, expensive, difficult to reproduce complex geometries.