Table 2:

Estimates used in the Markov model with their primary assigned values and probability distributions.

Variable description	Base estimate	Probability distribution	Reference
Cost
Rituximab (per 1 g)	$9395	Normal	[10]
Cyclosporine (per 1 mg)	$0.058	Normal	[10]
1 year of dialysis treatment	$83 797	Normal	[21]
Organ acquisition for transplant	$70 747	Normal	[22]
First year of transplant	$77 883	Normal	[23]
Subsequent years of transplant	$23 555	Normal	[23]
Utility
Treatment	0.702	Normal	MENTOR study data
CR (varied by time since treatment initiation)	0.875–0.930	Normal
PR (varied by time since treatment initiation)	0.735–0.767	Normal
No remission	0.702	Normal
Kidney failure on dialysis	0.71	Normal	[13]
Kidney failure with a functioning transplant	0.82	Normal	[13]
Probability estimates beyond 24 months in modela
Probability of reaching kidney failure	varied by time after treatment initiation	N/A	[2]
Probability of death on dialysis	varied by age	NA	[21]
Probability of transplantation after progression to kidney failure	varied by age	NA	[21]
Probability of transplant failure	varied by age	NA	[21]
Relative risk of death in patients with NR to treatment	1.69	Normal	[12]
Risk of death from natural causes	varied by age	NA	[24]

^aTransition probabilities for the first 24 months obtained directly from MENTOR study data are detailed in Supplementary Table S2.