Table 1.
Disulfidptosis-related genes and functions [35].
| Category | Gene | Gene Function | Expression in Disulfidptosis |
|---|---|---|---|
| Amino Acid/Nutrient Transport | SLC7A11 | Responsible for amino acid (e.g., cystine) transport, involved in antioxidant stress response | Upregulated |
| SLC3A2 | Forms a heterodimer with SLC7A11, cooperatively transports amino acids | Upregulated | |
| GLUT1 | Primarily responsible for transmembrane glucose transport, major carrier for glucose uptake | Downregulated | |
| GLUT3 | High glucose affinity, primarily expressed in neurons, involved in glucose uptake | Downregulated | |
| Cytoskeleton and Signal Transduction | NCKAP1 | A member of the WAVE complex, which helps with changing the cell’s structure and is linked to cell movement | Upregulated |
| CYFIP1 | A member of the WAVE complex, which helps with changing the cell’s structure and is linked to cell movement | Upregulated | |
| WAVE2 | A member of the WAVE complex, which helps with changing the cell’s structure and is linked to cell movement | Upregulated | |
| ABI2 | A member of the WAVE complex, which helps with changing the cell’s structure and is linked to cell movement | Upregulated | |
| HSPC300 | A member of the WAVE complex, which helps with changing the cell’s structure and is linked to cell movement | Upregulated | |
| RAC1 | Small GTPase, regulates the cytoskeleton, plays a key role in cell migration and adhesion | Upregulated | |
| Endoplasmic reticulum stress response | RPN1 | Involved in post-translational modification and degradation of proteins, key protein in ER glycosylation | Upregulated |
| ATF4 | Transcription factor, plays a role in cellular stress response, regulates gene expression | Upregulated | |
| Mitochondrial Function and Energy Metabolism | NUBPL | Mitochondrial assembly factor that is involved in putting together mitochondrial respiratory chain complex I | Downregulated |
| NDUFA11 | A part of mitochondrial respiratory chain complex I, which is involved in moving electrons and making ATP. | Downregulated | |
| LRPPRC | Regulates mitochondrial gene expression, influences oxidative phosphorylation process | Downregulated | |
| OXSM | Involved in fatty acid oxidation, part of the mitochondrial β-oxidation pathway | Downregulated | |
| NDUFS1 | A main part of mitochondrial respiratory chain complex I, which is involved in oxidative phosphorylation | Downregulated | |
| Glucose Metabolism | GYS1 | Glycogen synthase, involved in glycogen synthesis, affects energy storage | Downregulated |
| G6PD | Responsible for the first step of the pentose phosphate pathway, produces NADPH for reductive biosynthesis | Downregulated | |
| 6-PGD | Involved in the pentose phosphate pathway | Downregulated | |
| TALDO1 | Involved in the pentose phosphate pathway, generates nucleotides and NADPH | Downregulated | |
| TKT | Key enzyme in the pentose phosphate pathway, involved in carbon skeleton rearrangement | Downregulated | |
| Cell Division | PRC1 | Regulates the cell division process, particularly playing a role in cytokinesis during the final stages of cell division | Downregulated |