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Synthesis (A,B) and bioprofile (C) of benzoxazole derivatives. * VEGFR-2 protein concentration (pg/mL) in HepG2 cells. (HepG2: hepatic carcinoma cells; HCT-116: colon cancer cells; MCF-7 and MDA-MB-231: breast cancer cells; A549: lung cancer cells; HUVEC: human umbilical vein endothelial cells; Sor: sorafenib; PPA: polyphosphoric acid; EDCI: 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide; TEOA: triethanolamine).
