Table 4.
Univariate and multivariate cox regression analysis for predicting overall survival
| Covariate* | Univariate HR (95% CI) |
P value | Multivariate HR (95% CI, FWU model) |
P value |
|---|---|---|---|---|
| Age, years† | 1.065 (1.040; 1.081) | <.001 | ||
| Sex (women vs men) | 0.617 (0.424; 0.897) | .012 | 0.463 (0.298; 0.720) | <.001 |
| ASA-PS | 2.133 (1.509; 3.013) | <.001 | 1.584 (1.103; 2.274) | .013 |
| Stage (III vs I–II) | 4.684 (3.377; 6.497) | <.001 | 2.675 (1.867; 3.831) | <.001 |
| Histology (intestinal vs others) | 1.052 (0.763; 1.451) | .757 | ||
| Lymphatic invasion (yes vs no)† | 2.829 (2.047; 3.909) | <.001 | ||
| Vascular invasion (yes vs no) | 3.695 (2.276; 5.998) | <.001 | 1.752 (1.032; 2.972) | .038 |
| Perineural invasion (yes vs no)† | 2.028 (1.288; 3.194) | .002 | ||
| TOG (total vs partial) | 2.252 (1.599; 3.172) | <.001 | 1.637 (1.150; 2.331) | .006 |
| WBC, per μL | 1.000 (1.000; 1.000) | .391 | ||
| Hemoglobin, g/dL | 0.774 (0.729; 0.822) | <.001 | 0.905 (0.841; 0.974) | .008 |
| MCV, fL | 0.972 (0.954; 0.991) | .005 | ||
| Platelet, ×103/μL | 1.002 (1.000; 1.004) | .134 | ||
| NLR | 1.163 (1.096; 1.234) | <.001 | ||
| PLR | 1.006 (1.004; 1.008) | <.001 | ||
| LMR | 0.838 (0.749; 0.937) | .002 | ||
| SII | 1.000 (1.000; 1.000) | <.001 | ||
| Albumin, g/dL | 0.185 (0.139; 0.247) | <.001 | 0.388 (0.266; 0.565) | <.001 |
| BMR (FWU) | 0.999 (0.998; 0.999) | <.001 | 0.999 (0.998; 0.999) | <.001 |
ASA-PS = American Society of Anesthesiologists Physical Status, CI = confidence interval, FWU = the Food and Agriculture Organization/World Health Organization/United Nations University, HR = hazard ratio, LMR = lymphocyte/monocyte ratio, MCV = mean corpuscular volume, NLR = neutrophil/lymphocyte ratio, PLR = platelet/lymphocyte ratio, SII = systemic immune-inflammation index, TNM = Tumor-Node-Metastasis, TOG = type of gastrectomy, WBC = white blood cell.
*
The right-hand values in parentheses are the reference values.
†
Not compatible with the assumption of proportional hazards.