Table 1.

Advancements in research on certain p53 gene therapy products.

Name	Vector	Phase	Indication	Outcome	Ref.
Gendicine	RDAd	Approved in China	Head and neck squamous cell carcinoma, etc.	Safe and effective.	[24]
INGN 201 (Advexin)	RDAd	I/II	Esophageal squamous cell carcinoma, etc.	Safe, feasible, and biologically active.	[25]
SCH-58500 (ACN53)	RDAd	I/II	Recurrent ovarian cancer, primary peritoneal cancer, fallopian tube cancer, etc.	Safe and well-tolerated.	[26]
ONYX-015 (dl1520)	CRAd	I/II	Advanced sarcoma, etc.	Well-tolerated.	[27]
Oncoline (H101)	CRAd	Approved in China	Nasopharyngeal carcinoma, etc.	Safe and effective.	[28]
OBP-702	CRAd	In vitro and in vivo	Diffuse-type gastric cancer cells	Inhibit tumor growth in mice and induce cell apoptosis and autophagy.	[29]
SG600-p53	CRAd	In vitro and in vivo	Non-small cell lung cancer cells	Selective replication in tumors and anti-tumor effects.	[30]
SG635-p53	CRAd	In vitro and in vivo	Liver cancer cells	Inhibit tumor growth and prolong animal survival.	[31]
AdDelta24-p53	CRAd	In vitro and in vivo	Malignant glioma, etc.	Relieve tumors and prolong animal survival.	[32]
dl922-947	CRAd	In vitro and in vivo	Breast cancer cells	Demonstrate anti-tumor efficacy in vivo and in vitro.	[33]
rVV-TK-53	Vaccinia virus	In vitro and in vivo	Bladder cancer cells	Inducing the extinction of tumor cells.	[34]
SGT-53	Liposome nanoparticles	II	Pancreatic adenocarcinoma	Clinically significant benefits	[35]
CM@MnO2-PEI-NLS-ss/p53	Polyethylenimine	In vitro and in vivo	Malignant melanoma cells	Targeting cancer cells with high specificity and inhibiting tumor growth.	[36]
AP-PAMAM/p53	Polyamide amine dendritic polymer	In vitro	Cervical cancer cells	Anti-tumor proliferation, induction of cell apoptosis, inhibition of cancer cell migration and invasion.	[37]
LA-OEI/p53	Lipoic acid-modified oligoethylenimine	In vitro	Cervical cancer cells	Inhibit cell migration.	[38]
PBAE537	Poly (Beta-Amino Ester) Complex Nanoparticles	In vitro and in vivo	Cervical cancer cells	Successfully reversed cervical intraepithelial neoplasia in HPV transgenic mice.	[39]
DPD/pEGFP-C1-p53	Dextran-graft-poly ((2-dimethyl amino) ethyl methacrylate)	In vitro and in vivo	Breast cancer cells	Inhibit tumor cell proliferation.	[40]
micelles/DOX/p53	POSS-based star-shaped polymer	In vitro and in vivo	Breast cancer cells	Inducing apoptosis of tumor cells.	[41]
P-CSSO/p53	PEG modified glycolipid-like polymer	In vitro and in vivo	Liver cancer cells	The tumor inhibition rate can reach 77.1%.	[42]
AuNPs-p53	Gold nanoparticles	In vitro	Lung cancer cells	Low toxicity in normal cells, triggering apoptosis in tumor cells.	[43]
MB-NSi-p53-CS	Silica-polymer composite nano system	In vitro and in vivo	Lung cancer cells	Low cytotoxicity, high p53 transfection, and anticancer efficacy.	[44]
PCN-P53	Highly water-dispersible polymeric carbon nitride (PCN) nanosheets	In vitro and in vivo	Cervical cancer cells	Efficient DNA condensation, outstanding biocompatibility, transfection tracking, light responsiveness, and high transfection efficiency.	[45]
EPM-pcDNA-p53	Bovine colostrum exosomes and polyethyleneimine matrix	In vitro and in vivo	Lung cancer cells	Inhibiting the proliferation of tumor cells.	[46]
χ11218 pYA4545p53 strain	χ11218 strain of Salmonella typhimurium	In vitro	Bladder cancer cells	Decrease the vitality of human bladder cancer cells.	[47]
p53/C-rNC/L-FA	Liposome nanoparticles	In vitro and in vivo	Breast cancer cells	Inducing tumor cell apoptosis and inhibiting tumor growth.	[48]
RHD/p53	Cationic peptide	In vitro and in vivo	Cervical cancer cells	Demonstrate anti-tumor efficacy in vivo and in vitro.	[49]
FK/p53/PEG-PLL (DA)	Cationic peptide	In vitro and in vivo	Cervical cancer cells	Demonstrate anti-tumor efficacy in vivo and in vitro.	[50]

Note: RDAd: replication defective adenovirus; CRAd: conditional replication adenovirus.