FIGURE 4.

Activated HSCs are a candidate in vivo target population for INT-767 in murine MASH. (A) UMAP showing annotation of mouse liver scRNA-seq data (33,168 cells) by cell lineage. (B) UMAP showing whether cells are from healthy (n = 3) or MASH livers (n = 3). (C) Normalized expression level of the stated gene in each mouse liver cell lineage. (D) UMAP showing annotation of 429 mouse liver mesenchymal single cells as portal fibroblasts, quiescent HSCs, activated HSCs, or mesothelia. (E) UMAP showing whether mesenchymal cells are from healthy (n = 3) or MASH livers (n = 3). (F) Normalized expression level of the stated gene in each mouse liver mesenchymal cell type. Abbreviations: MASH, metabolic dysfunction–associated steatohepatitis; MP, mononuclear phagocyte; scRNA-seq, single-cell RNA-sequencing.