FIGURE 5.

Human SAMes are a candidate target population for INT-767. (A) UMAP showing annotation of human liver scRNA-seq data (58,358 cells) by cell lineage (B) UMAP showing whether cells are from healthy (n = 5) or cirrhotic livers (n = 5). (C) Dot plot showing normalized expression level (color) and percentage of cells (dot size) expressing the stated gene in each cell lineage. (D) UMAP showing annotation of 2316 human liver mesenchymal single cells as VSMC, HSCs, mesothelia, or SAMes. (E) UMAP showing whether mesenchymal cells are from healthy (n = 5) or cirrhotic livers (n = 5). (F) Normalized expression level of the stated gene in each human liver mesenchymal cell type. Abbreviations: SAMes, scar-associated mesenchymal cells; scRNA-seq, single-cell RNA-sequencing; VSMC, vascular smooth muscle cells.