Table 1.
Characteristics of patients with improved, static, and worsened splenic stiffness
| Improved N = 9 (A) | Static N = 51 (B) | Worsened N = 9 (C) | C vs B P valuea |
A vs B P valuea |
A vs others P valueb |
|
| Demographicsc | ||||||
| Age at admission, yr | 55 (12) | 44 (12) | 45 (13) | 0.94 | 0.033* | 0.017* |
| Male sex, n (%) | 9 (100) | 32 (63) | 7 (78) | 0.049* | ||
| White race, n (%)d | 7 (77) | 33 (65) | 5 (56) | 0.48 | ||
| Black race, n (%) | 2 (22) | 11 (22) | 3 (33) | |||
| Other race, n (%) | 0 (0) | 7 (14) | 1 (11) | |||
| Initial laboratory valuesc | ||||||
| ALT | 31 (15) | 53 (47) | 61 (57) | 0.33 | 0.88 | 0.006* |
| AST | 48 (24) | 76 (88) | 77 (53) | 0.99 | 0.55 | 0.044* |
| Total bilirubin | 0.71 (0.31) | 0.73 (1.36) | 0.49 (0.19) | 0.82 | 0.99 | 0.91 |
| Alkaline phosphatase | 90 (22) | 85 (36) | 86 (38) | 0.99 | 0.92 | 0.72 |
| Platelets | 164 (54) | 235 (109) | 183 (66) | 0.29 | 0.10 | 0.011* |
| INR | 1.11 (0.15) | 1.01 (0.12) | 1.06 (0.06) | 0.45 | 0.056 | 0.040* |
| Albumin | 4.20 (0.37) | 4.49 (0.37) | 4.66 (0.46) | 0.41 | 0.081 | 0.026* |
| GGT | 103 (66) | 257 (482) | 228 (206) | 0.98 | 0.53 | 0.019* |
| Creatinine | 0.83 (0.18) | 0.73 (0.15) | 0.85 (0.39) | 0.20 | 0.34 | 0.28 |
| Glucose | 113 (21) | 100 (23) | 104 (23) | 0.83 | 0.23 | 0.14 |
| Ferritin | 455 (655) | 412 (707) | 695 (1,313) | 0.55 | 0.99 | 0.99 |
| CRP | 2.41 (1.70) | 4.31 (8.74) | 1.82 (1.84) | 0.60 | 0.74 | 0.21 |
| ESR | 11.0 (11.6) | 10.6 (10.0) | 14.0 (9.2) | 0.58 | 0.99 | 0.98 |
| Fib-4 score | 2.89 | 1.95 | 2.42 | |||
| Final laboratory valuesc | ||||||
| ALT | 33 (14) | 29 (18) | 42 (26) | 0.12 | 0.75 | 0.70 |
| AST | 31 (7) | 26 (14) | 33 (15) | 0.30 | 0.55 | 0.22 |
| Total bilirubin | 0.46 (0.21) | 0.49 (0.87) | 0.32 (0.13) | 0.79 | 0.99 | 0.93 |
| Alkaline phosphatase | 73 (21) | 71 (28) | 74 (35) | 0.93 | 0.98 | 0.90 |
| Platelets | 233 (85) | 268 (79) | 230 (82) | 0.35 | 0.40 | 0.31 |
| Albumin | 3.83 (0.36) | 4.08 (0.43) | 4.07 (0.47) | 0.99 | 0.20 | 0.11 |
| GGT | 60 (35) | 89 (118) | 110 (116) | 0.84 | 0.72 | 0.10 |
| Creatinine | 0.80 (0.18) | 0.78 (0.16) | 0.88 (0.36) | 0.31 | 0.95 | 0.94 |
| Glucose | 98 (8) | 99 (15) | 95 (6) | 0.71 | 0.99 | 0.99 |
| Ferritin | 172 (123) | 173 (185) | 234 (267) | 0.62 | 0.99 | 0.88 |
| CRP | 1.68 (1.27) | 3.95 (6.74) | 3.26 (2.25) | 0.94 | 0.50 | 0.021* |
| ESR | 11.9 (8.7) | 14.8 (11.2) | 24.1 (20.5) | 0.08 | 0.76 | 0.34 |
| Fib-4 score | 1.27 | 0.79 | 1.00 | |||
| Transient elastographyc | ||||||
| Interval first to last scan, d | 20.4 (1.3) | 19.7 (3.2) | 20.3 (0.9) | 0.78 | 0.71 | 0.28 |
| Week 1 | ||||||
| LSM, kPa | 19.1 (27.4) | 8.0 (10.2) | 9.1 (5.0) | 0.97 | 0.044 | 0.27 |
| Liver CAP | 258 (55) | 258 (58) | 276 (36) | 0.60 | 0.99 | 0.87 |
| SSM, kPa | 54.9 (16.7) | 18.7 (12.3) | 17.2 (6.5) | 0.93 | <0.001* | <0.001* |
| Week 4 | ||||||
| LSM, kPa | 16.3 (22.4) | 7.7 (10.1) | 8.1 (6.8) | 0.99 | 0.097 | 0.29 |
| Liver CAP | 227 (73) | 238 (55) | 232 (57) | 0.95 | 0.84 | 0.63 |
| SSM, kPa | 18.4 (13.4) | 18.9 (13.3) | 45.4 (15.2) | <0.001* | 0.99 | 0.44 |
ALT, alanine aminotransaminase; AST, aspartate aminotransferase; CAP, controlled attenuation parameter; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; GGT, gamma-glutamyl transferase; INR, international normalized ratio; LSM, liver stiffness measurement; SSM, splenic stiffness measurement.
a
P value for worse vs static or better vs static adjusting for multiple comparisons using Dunnett's correction.
b
P value for better vs same or worse from t test with unequal variances or Fisher exact test.
c
Mean (SD) or n (%).
d
P value is for White race vs others.
*
P value <0.05 denotes statistical significance.