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. 2024 Nov 7;14(11):601. doi: 10.3390/metabo14110601

Figure 4.

Figure 4

Correlations of bone and angiogenesis biomarkers in Gaucher disease patients. In the overall population, a positive correlation was observed between (a) MMP-2 and osteopontin (r = 0.20, p-value = 0.022) and (b) MMP-9 and VEGF-C (r = 0.52, p-value < 0.001). Osteopontin was also positively correlated with other markers of Gaucher disease severity, such as (c) ferritin (r = 0.42, p-value = 0.001), (d) PARC/CCL18 (r = 0.21, p-value = 0.012), (e) ACE (r = 0.20, p-value = 0.044) and (f) chitotriosidase (r = 0.18, p = 0.053). The correlation between continuous variables was assessed with Spearman’s rank correlation coefficient. (●) Osteonecrosis-free; (●) historical osteonecrosis; (●) incident osteonecrosis. ACE = angiotensin-converting enzyme; MMP = matrix metalloproteinase; ON = osteonecrosis; PARC/CCL18 = CC chemokine pulmonary and activation-regulated chemokine; VEGF-C = vascular endothelial growth factor C.