Table 2.
Biochemistry parameters of the study cohort by osteonecrosis status.
| Variable | Osteonecrosis—Free | Osteonecrosis—Historical | Osteonecrosis—Incident | p-Value |
|---|---|---|---|---|
| Haemoglobin, g/L, median (IQR) |
139 (129–146.5) |
136 (131–150) |
137 (128–152) |
0.873 |
| White cell count, ×109/L, median (IQR) |
5.7 (4.7–7.5) |
6.4 (5.0–8.4) |
6.6 (3.7–9) |
0.319 |
| Platelets, ×109/L, median (IQR) |
178 (145–219) |
194 (160–252) |
237 (152–325) |
0.043 2 ≠ 0 ‡ |
| Alkaline phosphatase, U/L, median (IQR) | 67.5 (55.8–84) |
67 (56–83) |
73 (55.5–95.3) |
0.864 |
| Calcium, mmol/L, median (IQR) |
2.3 (2.3–2.4) |
2.4 (2.3–2.4) |
2.3 (2.3–2.4) |
0.229 |
| Corrected calcium, mmol/L, median (IQR) | 2.4 (2.3–2.5) |
2.4 (2.3–2.5) |
2.4 (2.4–2.4) |
0.300 |
| Vitamin D, ug/L, median (IQR) |
61.1 (43–84.5) | 58.3 (39.8–82.0) |
56.8 (40.1–67.7) |
0.749 |
| Vitamin B12, ng/L, median (IQR) |
405 (310–556) |
399 (317.5–507) |
425 (356–538) |
0.861 |
| Ferritin, ug/L, median (IQR) |
153 (76.3–535.3) |
190 (119.2–371.1) |
73.8 (27.8–460.5) |
0.332 |
| ACE, U/L, median (IQR) |
40 (25–58) |
51 (38–80) |
66 (35–87) |
0.040 2 ≠ 0 ‡ |
| Chitotriosidase, umol/L/h, median (IQR) |
303 (125.5–878) |
519 (254.5–1301.5) |
479.5 (199.5–2138.3) |
0.128 |
| PARC/CCL18, ng/mL, median (IQR) |
149.5 (104.3–251.5) |
209 (117.3–378.8) |
224 (171–391.8) |
0.055 |
| Fibrinogen, g/L, median (IQR) |
2.67 (2.02–3.17) |
2.59 (2.16–2.83) |
2.92 (2.66–3.1) |
0.141 |
Continuous variables presented as median (interquartile range, IQR). ACE = angiotensin-converting enzyme; PARC/CCL18 = CC chemokine pulmonary and activation-regulated chemokine. Kruskal–Wallis one-way ANOVA test; ‡ Dunn’s post-hoc test (0 = osteonecrosis-free; 1 = historical osteonecrosis; 2 = incident osteonecrosis).