Table 1.
Information on GWAS summary statistics for exposure and outcomes in the TSMR.
| Type | Variable | Sample Size | Population | Data Download Address |
|---|---|---|---|---|
| Exposures | Vitamin B12 | 462,933 | European | https://gwas.mrcieu.ac.uk/datasets/ukb-b-18819/ (accessed on 5 April 2024) |
| Vitamin B6 | 64,979 | European | https://gwas.mrcieu.ac.uk/datasets/ukb-b-7864/ (accessed on 5 April 2024) | |
| Folic acid product | 462,933 | European | https://gwas.mrcieu.ac.uk/datasets/ukb-b-288/ (accessed on 5 April 2024) | |
| Vitamin B compound tablet | 462,933 | European | https://gwas.mrcieu.ac.uk/datasets/ukb-b-2669/ (accessed on 5 April 2024) | |
| Mediators | Gut bacteria | 18,340 | European | https://mibiogen.gcc.rug.nl/ (accessed on 5 April 2024) |
| Outcomes | Alzheimer’s disease | 488,285 | European | https://gwas.mrcieu.ac.uk/datasets/ieu-b-5067/ (accessed on 5 April 2024) |