Figure 4.

Protein interaction network and impacted biological functions generated by the hypothesis-generating pathway explorer tool depicting SPON-1 interaction with E2. No direct interaction between the ER and SPON-1 was found by IPA^®. Blue and orange colors represent proteins’ predicted activation and suppression by the MAP tool of IPA^®, respectively. Red and green colors denote proteins which were found to increase and decrease, respectively. Teal solid and dashed lines indicate the closest relationship pattern of SPON1 with other proteins. The intensity of the colors represents fold change or the Z score for the prediction. Solid and dashed lines represent direct and indirect interactions.