Table 1.
IPA®’s top canonical pathways regulated in the SVs upon E2 treatment. Positive Z score values predict activation, while negative Z scores forecast suppression. N/A represents no predictions made.
| Canonical Pathways | Number of Associated Molecules |
−log (p Value) | Z Score |
|---|---|---|---|
| Neutrophil degranulation | 37 | 17.5 | −1.732 |
| Response to elevated platelet cytosolic Ca2+ | 10 | 7.83 | 1.265 |
| Apoptotic execution phase | 7 | 7.36 | −2.0646 |
| Gene and protein expression by Jak-STAT signaling pathway after IL-12 stimulation | 6 | 6.88 | 0.816 |
| Granzyme A signaling | 6 | 5.13 | 2.449 |
| Cellular response to heat stress | 6 | 4.39 | 0.449 |
| Dissolution of fibrin clot | 3 | 4.14 | N/A |
| Glutamate and glutamine metabolism | 3 | 4.03 | N/A |
| Trans-Golgi network vesicle budding | 5 | 3.92 | −1.342 |
| Metabolism of angiotensinogen to angiotensin | 3 | 3.69 | N/A |