Figure 4.

APP as a mechanocoupler coupling the two cells force-generation machineries through the talin mechanically operated signalling scaffolds. (a) Cartoon representation and (b) structural model of four APP molecules, two from each side of the synapse forming a meshwork that spatially positions four talin binding sites, which can then recruit four talin molecules to connect the synaptic junction to the actin and microtubule cytoskeletons. The coupling to the actin cytoskeleton through talin is shown by black arrows.