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. 2024 Nov 2;17(11):1477. doi: 10.3390/ph17111477

Figure 4.

Figure 4

Evaluation of gene expression in the inflammasome pathway (NLRP3 (A), CASP-1 (B), IL-1β (C), and IL-18 (D)) and the isoenzymes CYP2E1 (E) and CYP1A2 (F) in the mice subjected to prophylactic treatment with piperine for 8 days, followed by APAP intoxication. The different letters indicate statistical differences between the groups: any letter other than “a” signifies a difference from the control group, and any letter other than “b” signifies a difference from the APAP group. The notation “ab” is used when the statistical analysis indicates that a group is statistically equal to both the control and APAP groups, as determined by a one-way analysis of variance followed by Tukey’s post hoc test. Abbreviations: NLRP3: NLR family pyrin domain-containing protein 3; CASP-1: caspase-1; IL-1β: interleukin-1β; IL-18: interleukin-18; CYP1A2: cytochrome P450 1A2; CYP2E1: cytochrome P450 2E1.