Table 7.

Heterogeneity and pleiotropy tests.

Exposure	Outcome	Heterogeneity Test MR–Egger		Heterogeneity Test IVW		Pleiotropy Test MR–Egger
		Q	p	Q	p	Intercept	p
Relative carbohydrate intake	Heart failure	70.511	<0.001	78.254	<0.001	−0.013	0.051
	Coronary artery disease	82.673	<0.001	82.675	<0.001	<0.001	0.976
	Stroke	64.774	0.010	64.791	0.014	<0.001	0.918
	Hypertension	100.365	<0.001	101.891	<0.001	0.001	0.440
Relative fat intake	Heart failure	34.434	0.077	35.089	0.087	0.005	0.506
	Coronary artery disease	33.992	0.085	35.359	0.082	0.008	0.336
	Stroke	44.966	0.030	45.120	0.038	<0.001	0.754
	Hypertension	61.165	<0.001	61.349	<0.001	<0.001	0.782
Relative protein intake	Heart failure	40.098	0.065	40.298	0.079	0.002	0.711
	Coronary artery disease	25.615	0.646	27.551	0.594	0.007	0.175
	Stroke	32.983	0.517	32.986	0.566	<0.001	0.957
	Hypertension	27.338	0.605	29.861	0.524	−0.001	0.123
Relative sugar intake	Heart failure	31.477	0.392	34.639	0.298	−0.011	0.093
	Coronary artery disease	57.634	0.003	57.991	0.003	−0.004	0.665
	Stroke	131.978	<0.001	132.299	<0.001	<0.001	0.776
	Hypertension	29.916	0.789	29.996	0.820	<0.001	0.778