Figure 3.

Following orofacial CFA inflammation, the hyper-excitability of SpVc WDR neuronal activity was reversed by the administration of chronic NRG, DIC, and a mix of 1/2 DIC and 1/2 NRG. Example showing the reaction of SpVc WDR neurons to non-noxious and noxious mechanical stimuli in subjects that are naïve (A), suffering from inflammation (B), and suffering from inflammation treated with NRG (50 mg/kg, i.p. for two days) (C), inflamed with DIC (50 mg/kg, i.p. for two days) (D) and inflamed with 1/2 DIC + 1/2 NRG (for two days) rats (E). It should be noted that a lower threshold for mechanical stimulation is needed to trigger neuronal activity, which also results in more frequent spontaneous nerve impulses and increased receptive field size in inflamed rats returned to control levels following NRG, DIC, 1/2 DIC + 1/2 NRG administration for two days.