Skip to main content
. 2024 Nov 15;16(22):3895. doi: 10.3390/nu16223895

Figure 4.

Figure 4

A summary of persistent NRG or DIC treatments, alongside a combination therapy of half DIC and half NRG, restored elevated SpVc WDR neuronal activity following orofacial inflammation induced by CFA inflammation. (A) Analysis of the average discharge rate of SpVc WDR neurons in response to both non-noxious and noxious mechanical stimulation of orofacial skin across the five groups (each group, n = 6). * p < 0.05 comparing naïve vs. inflamed rats and inflamed vs. inflamed with NRG or DIC and inflamed with 1/2 DIC + 1/2 NRG. (B) Evaluating the mean mechanical threshold of SpVc WDR neurons across the five groups of rats. * p < 0.05 comparing naïve vs. inflamed rats and inflamed vs. inflamed with NRG or DIC and inflamed with 1/2 DIC + 1/2 NRG. (C) Spontaneous activity of SpVc WDR neurons across the five groups of rats. * p < 0.05 comparing naïve vs. inflamed rats and inflamed vs. inflamed with NRG or DIC and inflamed with 1/2 DIC + 1/2 NRG. (D) An analysis of the differences in mean receptive field sizes of SpVc WDR neurons among the five rat groups. * p < 0.05 comparing naïve vs. inflamed rats and inflamed vs. inflamed with NRG or DIC and inflamed with 1/2 DIC + 1/2 NRG.