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Main therapeutic oligonucleotide (tON) mechanisms of action: (a)—RNase H-dependent mechanism of mRNA degradation; (b)—regulation of mRNA maturation process (regulation of splicing, inhibition of capping, inhibition of polyadenylation); (c)—blocking the landing site of the ribosome, resulting in the inhibition of translation; (d)—RNA interference; (e)—altering protein conformation and functions.
