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Biological barriers that influence the pharmacokinetic characteristics of oligonucleotide-based drugs: (a)—nuclease degradation; (b)—reticuloendothelial system; (c)—blocking the lateral movement of oligonucleotide from the vessel lumen into the interstitial fluid; (d)—low efficiency of cell penetration; (e)—endo-lysosomal entrapment; (f)—blood–brain barrier.
