Table 2.

K_d of the complexes of albumin with modified oligonucleotides.

Modification	Site of Modification	Kd, μM	References
	sugar backbone, 2′-OH	>400	[145]
	inter-nucleotide phosphate	4–7	[145]
	3′-end of ON	8–12	[145]
	3′-end of ON	0.227	[124]
	3′-end of ON	0.024	[124]
	3′-end of ON	0.218	[124]
	3′-end of ON	0.041	[146]
	inter-nucleotide phosphate	1.2–1.5	[130]
	3′- and 5′ ends of aptamer	0.1–1	[147]