AMP	5′-adenosine monophosphate
AMPK	AMP-activated protein kinase
CMP	5′-cytimidine monophosphate
Control	normal control group
CS	citrate synthase
CVD	cardiovascular disease
DEMs	differentially expressed metabolites
GMP	5′-guanosine monophosphate
GSH-Px	glutathione peroxidase
HE	hematoxylin-eosin
IL-1β	interleukin-1 β
IL-6	interleukin-6
IMP	inosinic acid
MDA	malondialdehyde
NTs	nucleotides
NTs_H	high-dose NTs group
NTs_L	low-dose NTs group
OPLS-DA	orthogonal projections to latent structures-discriminate analysis
OXPHOS	oxidative phosphorylation
PCA	principal component analysis
PGC-1α	peroxisome proliferator-activated receptor-gamma coactivator-1α
ROS	reactive oxygen species
SAMP8	senescence-accelerated mouse prone-8
SAMR1	senescence-accelerated mouse resistant 1
SDH	succinate dehydrogenase enzyme
SOD	superoxide dismutase
SPF	specific-pathogen free
TFAM	mitochondrial transcription factor A
TNF-α	tumor necrosis factor-α
UMP	5′-disodium uridine monophosphate
VIP	variable importance in the projection