Table 1.
Genetic factors contributing to gout risk [50].
| Gene Function | Gene Name | Gene Product | Location |
|---|---|---|---|
| Production of uric acid | HPRT1 | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Xq26.2-26.3 |
| PRPS1 | Phosphoribosyl pyrophosphate synthetase 1 (PRPPS) | Xq22.3 | |
| XOR | Xanthine oxidoreductase | 2p23.1 | |
| ALDH16A1 | Aldehyde dehydrogenase 16 family A1 | 19q13.33 | |
| Excretion/Transport/Anion exchange/Renal drug excretion | SLC22A11 | Organic anion transporter 4 (OAT4) | 11q13.1 |
| UOX | Uricase (UOX) | 1p22.1 | |
| SLC22A12 | Urate transporter 1 (URAT1) | 11q13.1 | |
| SLC22A13 | Organic anion transporter 10 (OAT10) | 3p22.2 | |
| SLC2A9 | Glucose transporter 9 (GLUT9) | 4p16.1 | |
| ABCG2 | ATP-binding cassette subfamily G member 2 (BCRP) | 4q22.1 | |
| ABCC4 | Multidrug resistance-associated protein 4 (MRP4) | 13q32.1 | |
| SLC17A1 | Sodium-dependent phosphate transport protein 17A1 | 6p22.2 | |
| SLC17A3 | Sodium-dependent phosphate transporter 17A3 | 6p22.2 | |
| SLC17A4 | Sodium-dependent phosphate transporter 17A4 | 6p22.2 | |
| SLC22A6 | Solute carrier family 22 member 6 (OAT1) | 11q13 | |
| SLC22A8 | Organic anion transporter 3 (OAT3) | 11q13 |