Table 1.

In vitro susceptibility of promastigotes and intracellular amastigotes of the L. (V.) guyanensis M4147 strain and the IMLC isolate to antileishmanial drugs.

Drugs	Promastigotes		Intracellular Amastigotes		CC50 c
	M4147	IMLC	M4147	IMLC
SbIII a	20.58 ± 2.88	10.82 ± 4.25	-	-	-
SbV a	-	-	>1000	221.8 ± 18	>2000
AmB b	31.73 ± 2.81	15.26 ± 2.43	13.11 ± 1.11	9.8 ± 2.95	127.36 ± 0.94
PEN a	0.41 ± 0.078	0.91 ± 0.07	>0.4	>0.4	0.36 ± 0.02
MF a	46.4 ± 4.37	21.52 ± 5.43	13.5 ± 4.52	9.05 ± 2.3	49.52 ± 2.93

^a EC₅₀ mean values ± standard deviation in µM of three independent experiments. ^b EC₅₀ mean values ± standard deviation in nM of three independent experiments. ^c The CC₅₀ values for SbV, AmB, PEN, and MF against BMDMs were previously determined [14]. (-) Data not determined.