Table 3.
Antimicrobial true alkaloid compounds 171–198.
| Type | Compound | Structure | Source | Antimicrobial Activity |
|---|---|---|---|---|
| Acridine | Shermilamine B [168] | 171 in Figure 10 | Ascidian C. dellechiajei. | Activity against E. coli and M. luteus, with MIC values ranging from 2.0 to 8.0 µM. |
| N-deacetylkuanoniamine D [168] | 172 in Figure 10 | Activity against E. coli and M. luteus, MIC values ranging from 2.5 to 5 µM. | ||
| N-deacetylshermilamine B [168] | 173 in Figure 10 | Activity against E. coli and M. luteus, MIC values ranging from 1.1 to 4.5 µM. | ||
| 11-hydroxyascididemin [168] | 174 in Figure 10 | Activity against E. coli and M. luteus, MIC values ranging from 2.6 to 10.5 µM. | ||
| Cystodimine A [171] | 175 in Figure 10 | Activity against E. coli and M. luteus, MIC values ranging from 1.2 to 2.4 µM. | ||
| Cystodimine B [171] | 176 in Figure 10 | Activity against E. coli and M. luteus, MIC values ranging from 2.6 to 10.5 µM. | ||
| Ascididemin [171] | 177 in Figure 10 | Activity against E. coli and M. luteus, MIC values ranging from 0.2 to 0.3 µM. | ||
| Indole | Latifolianine A [172] | 178 in Figure 10 | Nauclea latifolia. | Activity against Haemophilus influenzae, with an MIC value of 25 µg/mL. |
| Latifoliaindole A [172] | 179 in Figure 10 | Activity against H. influenzae, with an MIC value of 50 µg/mL. | ||
| Latifoliaindole B [172] | 180 in Figure 10 | Activity against H. influenzae, with an MIC value of 25 µg/mL. | ||
| Alstoniascholarine A [173] | 181 in Figure 10 | Alstonia scholaris. | Activity against P. aeruginosa, K. pneumoniae, E. coli, and E. faecalis, with MIC values ranging from 25 to 50 μg/mL. | |
| Alstoniascholarine C [173] | 182 in Figure 10 | Activity against P. aeruginosa, K. pneumoniae, E. coli, and E. faecalis, with MIC values ranging from 12.5 to 50 μg/mL. | ||
| Alstoniascholarine E [173] | 183 in Figure 10 | Activity against P. aeruginosa, K. pneumoniae, E. coli, and E. faecalis, with MIC values ranging from 25 to 50 μg/mL. | ||
| Alstoniascholarine F [173] | 184 in Figure 10 | Activity against P. aeruginosa, K. pneumoniae, E. coli, and E. faecalis, with MIC values ranging from 3.13 to 50 μg/mL. | ||
| Alstoniascholarine H [173] | 185 in Figure 10 | Activity against P. aeruginosa, K. pneumoniae, and E. coli, with MIC values ranging from 25 to 50 μg/mL. | ||
| Alstoniascholarine I [173] | 186 in Figure 10 | Activity against P. aeruginosa, K. pneumoniae, and E. coli, with MIC values ranging from 12.5 to 25 μg/mL. | ||
| Alstoniascholarine J [173] | 187 in Figure 10 | Activity against S. aureus, P. aeruginosa, E. faecalis, K. pneumoniae and E. coli, MIC values ranging from 3.13 to 25 μg/mL. | ||
| Scholarisine T [174] | 188 in Figure 10 | Activity against E. coli, B. subtilis and S. typhi, MIC values ranging from 0.78 to 12.5 μg/mL. | ||
| Scholarisine U [174] | 189 in Figure 10 | Activity against E. coli and B. subtilis, MIC values ranging from 0.78 to 3.12 μg/mL. | ||
| Scholarisine V [174] | 190 in Figure 10 | Activity against E. coli, S. aureus and S. typhi, MIC values ranging from 0.78 to 12.5 μg/mL. | ||
| Imidazole | (2S)-2-Amino-3-(1-(((E)-2-benzylidenehydrazinyl)-(furan-2-yl)methyl)-1H-imidazol-4-yl)propanoic acid [175] | 191 in Figure 11 | Synthesized compound. | Antibacterial activity against S. aureus and K. pneumoniae, with an MIC value of 0.5 μg/mL. |
| (2S)-2-Amino-3-(1-(((E)-2-benzylidenehydrazinyl)-(4-methoxyphenyl)methyl)-1H-imidazol-4-yl)propanoic acid [175] | 192 in Figure 11 | Synthesized compound. | Antibacterial activity against K. pneumoniae, with an MIC value of 32 μg/mL. | |
| (2S)-2-Amino-3-(1-(((E)-2-benzylidenehydrazinyl)-(4-hydroxyphenyl)methyl)-1H-imidazol-4-yl)propanoic acid [175] | 193 in Figure 11 | Synthesized compound. | Antifungal activity against C. albicans, with an MIC value of 0.5 μg/mL. In addition, it possessed remarkable activity against A. niger, with an MIC value of 16 μg/mL, while the standard drug clotrimazole had an MIC value of 32 μg/mL. | |
| 2-cyclopropyl-5-(5-(6-methylpyridin-2-yl)-2-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole [176] | 194 in Figure 11 | Synthesized compound. | Antibacterial activity, with MIC values ranging from 1 to 2 μg/mL. | |
| 5-(2-(2-bromopyridin-4-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-2-cyclopropyl-6-phenylimidazo[2,1-b][1,3,4] thiadiazole [176] | 195 in Figure 11 | Synthesized compound. | Antibacterial activity, with an MIC value of 0.5 μg/mL. | |
| Purine | 5-((6-Morpholino-9H-purin-9-yl)methyl)-1,3,4-oxadiazole-2-Thiol [177] | 196 in Figure 11 | Synthesized compound. | Demonstrated strong inhibitory effect against Xanthomonas oryzae, with an EC50 value of 8.39 μg/mL. |
| 8-chloro-1,3-dimethyl-7-{2-[(4- methylphenyl)amino] ethyl}-3,7-dihydro-1H-purine-2,6-dione [178] | 197 in Figure 11 | Synthesized compound. | Antibacterial activity against E. coli, P. aeruginosa, B. subtilis, and S. aureus. | |
| 3,7-Dimethylisoguanine [179] | 198 in Figure 11 | Sponge A. dilatate | Activity against K. pneumoniae and P. aeruginosa |