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. 2024 Nov 13;15:1450751. doi: 10.3389/fphar.2024.1450751

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Copyright © 2024 Chen, Zhang, Wang, Ding and Chi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prediction of immunotherapy benefit based on Hypoxia-TME classifier. (A–D) TIDE, T-cell dysfunction and exclusion, and MSI score in different Hypoxia-TME subgroups. (E) Hypoxia and TME score in the IMvigor210 cohort. (F) The different percentages of anti-PD-L1 immunotherapy in different Hypoxia-TME subgroups. (G) Survival analysis of the Hypoxia-TME classifier in the IMvigor210 cohort. (H, I) The expression of activation and inhibitory immune markers in different Hypoxia-TME subgroups. (J) Immunofluorescence staining of HIF-1α and PD-L1 in HGSOC patients. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, not significant.