TABLE 1.

Univariate and multivariate Cox regression analyses of Hypoxia-TME classifier.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	p	HR (95% CI)	p
Stage
Stage II	1		1
Stage III	2.440 (1.002–5.941)	0.050	2.082 (0.840–5.163)	0.114
Stage IV	2.952 (1.164–7.483)	0.023	2.664 (1.030–6.890)	0.043
Grade
G2	1		1
G3	1.232 (0.832–1.823)	0.297	1.145 (0.768–1.709)	0.506
G4	1.851 (0.251–13.634)	0.546	2.567 (0.344–19.17)	0.358
Hypoxia-TME classifier
HypoxiaLow/TMEHigh	1		1
Mixed	1.566 (1.142–2.146)	0.005	1.631 (1.182–2.249)	0.003
HypoxiaHigh/TMELow	2.009 (1.455–2.774)	<0.001	2.050 (1.474–2.851)	<0.001