Table 2.
Case series or retrospective studies on the phenomenon of STM in teratomas.
| Authors | N. teratomas /N. of total cases |
Patients median age |
Stages at diagnosis (relative frequency) |
Primary site (Abs freq./Rel. freq.) |
Histology frequencies (absolute frequency) |
Possible prognostic factors |
|---|---|---|---|---|---|---|
|
(IQR
range) |
||||||
| 1. Rabdomiosarcoma (6) | ||||||
| 2. Other sarcomas (6) | ||||||
| 1. Testis: 7 | 3. Nefroblastoma (2) | Worse Prognosis: | ||||
| Ulbright et al. (1984) | 10/11 (91%) | 30 (13) | Not described | 2. Mediastinum: 3 3. Retroperitoneum: 1 |
4. Neuroblastoma (1) 5. Malignant giant cell tumor (1) |
Rhabdomyosarcoma Histologies |
| 6 Adenosquamous Ca (1) | ||||||
| 7. Gliobastoma (1) | ||||||
| 1. Carcinoma (6) | ||||||
| Comiter et al. (1998) | 21/21 (100%) | Not known | Stage I: 1 (5) Stage II-III: 20 (95) |
1. Testis: 18 2. Mediastinum: 2 3. Retroperitoneum: 1 |
2. Rhabdomyosarcoma (4) 3. Other sarcomas (6) 4. Malignant peripheral nerve sheath tumor (3) 5. PNET (2) |
Worse prognosis: a) Mediastinal primitivity, b) PNET and Rhabdomyosarcoma histologies |
| Motzer et al. (1998) | 26/46 (57%) | 27 (16-56) | Stage I: 4 (9) Stage II: 20 (43) Stage III: 22 (48) |
1. Testis: 36 2. Mediastinum: 9 3. Retroperitoneum: 1 |
1. Rhabdomyosarcoma (16) 2. Sarcoma NOS (11) 3. Adenocarcinomas (10) 4. PNET (7) 5. Leukemia/lymphoma (4) |
Worse Prognosis: a) Incomplete surgery b) Late stages c) Mediastinum as primary site vs Testis |
| 1. Rabdomiosarcoma (4) | ||||||
| Donadio et al. (2003) | Not known n =10 | 30 (19-55) | Stage I: 2 (20) Stage II: 2 (20) Stage III: 6 (60) |
1. Testis: 6 2. Mediastinum: 4 |
2. Adenocarcinoma (2) 3. Leukemia (2) 3. PNET (1) |
Better prognosis: SMT-oriented CT |
| 4. Anaplastic SCT (1) | ||||||
| Malagòn et al. (2007) | 42/46 (91%) | 26.5 (22-30) | Stage I: 4 (9) Stage II: 6 (13) Stage III: 28 (61) Unknown: 7 (13) |
1. Testis: 18 2. Mediastinum: 23 3. Retroperitoneum: 1 4. Ovary: 3 |
a) Rabdomiosarcoma (29) b) Angiosacroma (6) c) Leiomiasrcoma (4) d) Myxoid liposarcoma (1) e) MPNST (1) g) Epithelioid hemangio- endothelioma (1) |
Worse Prognosis: a) Sarcomatous SMT b) Primary site |
| El Mesbahi et al. (2007) | 8/14 (57%) | 29.5 (19-45) | Stage I: 3 (21) Stage II: 2 (14) Stage III: 9 (65) |
1. Testis: 9 2. Mediastinum: 4 3. Retroperitoneum: 1 |
1. Sarcoma (10) 2. Adenocarcinoma (3) 3. Broncoalveolar Ca (1) |
Worse Prognosis: a) Incomplete surgery b) SMT presence |
Ca, carcinoma; CHT, chemotherapy; CT, computed tomography; GCT, germ cell tumors; MPNST, Malignant Peripheral Nerve Sheath Tumors; NOS, not otherwise specified; PNET, primitive neuroectodermal tumor; RPLND, Retroperitoneal lymph node dissection; SMT, somatic-type malignancy.