Table 3.
Case reports available in the literature concerning the detection of a malignant somatic component attributable to melanoma in mediastinal teratomas.
| Author (Year) | Age | Initial Symptoms | Histology of biopsy | Pre-surgery chemotherapy (regimen) | Surgery of the primary tumor | Histology of the primary tumor | Post-surgery chemotherapy (regimen) | Recurrence site(s) | Histology of the recurrence |
|---|---|---|---|---|---|---|---|---|---|
| McNab et al. (2012) | 32 | Chest pain | Mixed GCT with seminoma, embryonal carcinoma and teratoma | Yes (BEP followed by TIP) |
Resection of the mediastinal mass | Mixed GCT with melanoma | No | Liver | Melanoma |
| Mustafa et al. (2016) | 21 | Cough, chest pain and dyspnea | Immature teratoma | Yes (BEP) | Resection of mediastinal mass along with a right bi-lobectomy | Immature teratoma with PNET, sarcoma, adenocarcinoma and melanomatous components | Yes (Temozolomide) | Bones and liver | Melanoma |
| Nozaki et al. (2018) | 14 | Cough | Necrotic tissue | Yes (cisplatin based chemotherapy) | Resection of mediastinal mass with a right pneumonectomy | Teratoma with areas of yolk sac tumor and melanoma | Yes (cisplatin based chemotherapy) | Bones and liver | Melanoma |
| Lee et al. (2020) | 34 | Chest pain | Mixed GCT with yolk sac and embryonal elements | Yes (BEP followed by VIP) |
Resection of the mediastinal mass, thymectomy and resection of left upper lobe | Mature teratoma with melanoma, yolk sac and embryonal elements | No | – | – |
BEP, bleomycin, etoposide and cisplatin; GCT, germ cell tumors; PNET, primitive neuroectodermal tumor; TIP, paclitaxel, ifosfamide, and cisplatin; VIP, etoposide, ifosfamide, and cisplatin.