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Host restriction factors and retroviral antagonists. Restriction factors are shown in red and viral antagonists are shown in blue. CypA: cyclophilin A; KZFPs: Kruppel-associated box (KRAB)-containing zinc finger proteins; HUSH: human silencing hub (HUSH) complex; Vpr: Viral protein R: Vif: Viral infectivity factor; Vpu: Viral protein U; APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G); SAMHD1: SAM domain and HD domain-containing protein 1.
