Status	Frequency	Comment
Yes	70%	The most common adaptation was the acidification of samples post-reaction to minimize the hydrolysis and migration of acyl glucuronide metabolites. Other functional groups considered for procedural adjustments included esters and amides prone to hydrolysis and alkenes prone to E/Z conversation from light. Respondents highlighted the importance of structural insight, availability of supplementary data, and method development, often aided by the availability of synthetic standards, to establish appropriate conditions before conducting in vitro studies
No	30%