Table 2.
Frequencies of QRDRs mutation amongst E.coli isolate highlighting co-occurrence of amino acid substitution within gyrase A (gyrA) and topoisomerase IV (parC).
| QRDRs mutations (N) | Isolates N (%) | Amino acid substitution | ||
|---|---|---|---|---|
| N (%) | GyrA | ParC | ||
| 1 | 11 (16,41%) |
7(10,44%) 1(1,49%) 1(1,49%) 2(1,49%) |
S83L S83T S83Y D87N |
- - - - |
| 2 | 11 (16,41%) |
5(7,46%) 4(5,97%) 1(1,49%) 1(1,49%) |
S83L + D87N S83L S83W D87N |
- S80I S80I S80I |
| 3 | 36 (53,73%) |
35(52,23%) 1(1,49%) |
S83L + D87N S83L + D87N |
S80I E84K |
| 4 | 9 (13,43%) |
7(10,44%) 1(1,49%) 1(1,49%) |
S83L + D87N S83L + D87N S83L + D87N |
S80I + E84V S80L + E84V S80I + E84G |
S: Serine; L: Leucine; I: Isoleucine; D: Aspartate; N: Asparagine; T: Threonine; Y: Tyrosine; W: Tryptophan; E: Glutamic acid; G: Glysine; V: Valine; K: Lysine.