Table 1.
Key residues phosphorylated on HSP70 and HSP90 and the downstream effects of phosphorylation
| Protein & phosphorylated residue | Modifier | Downstream impact | Preferred Co-Chaperone |
|---|---|---|---|
| HSP70 | |||
| Ser 385 (83) | ERK (83) | Chemo-resistance, Refolding | HOP |
| Ser400 (83) | ERK (83) | Chemo-resistance, Refolding | HOP |
| Thr636 (22) | AKT (88, 96) | Chemo-resistance, Refolding, and Increased Proliferation | HOP |
| Ser634 (22) | Refolding | HOP | |
| Ser631 (88, 108) | AKT (88) | Decreased mitosis | HOP |
| Ser633 (108) | AKT (88) | Decreased mitosis | HOP |
| HSP90 | |||
| Thr725 (22) | Decreased proliferation | HOP | |
| Ser726 (22) | Decreased proliferation | HOP | |
| Thr90 (93) | PKA (93) | Increased degradation | CHIP |
| Thr5/Thr7 (111) | Increased chemo-response | CHIP | |
| Thr115/T425/Thr603 (94) | Increased cell migration | HOP | |
Numbers in parentheses refer to references for papers that describe the modifications. All modifiers have been referenced accordingly.