Table 3.
Key residues phosphorylated on HSF1 and the downstream effects of phosphorylation
| Phosphorylated residue | Modifier | Downstream impact |
|---|---|---|
| Ser326 (135) | AKT1 (135) | Increased transcriptional activity |
| Thr142 (135) | AKT1 (135) | Increased trimerization |
| Ser230 (135) | HSR activation | |
| Ser326 (135) | HSR activation | |
| Thr527 (135) | HSR activation | |
| Ser303/Ser307 (136) | Decreased transcriptional activity | |
| Ser216 (139) | PLK1 (139) | Cell cycle progression |
| Ser419 (138) | PLK1 (140) | Increases transcription |
| Thr120 (141) | Increases proteostasis |
Numbers in parentheses refer to references for papers that describe the modifications. All modifiers have been referenced accordingly.