TABLE 5.
Immunogenicity and protective efficacy of the III-α2r conjugate vaccine in micea
| Immunizing antigen | Dose of immunization (μg/mouse)b | No. of pups alive/total no. of pups (% survival)c | Geometric mean titer of α2r-specific IgGd |
|---|---|---|---|
| III-α2r | 0.5 | 6/37 (16)* | 270 |
| III-α2r | 5 | 17/40 (43)** | 3,577 |
| III-α2r | 20 | 22/37 (60)*** | 8,170 |
| α2r (positive control) | 10 | 22/38 (58) | 14,969 |
| Saline (negative control) | 0 | 8/46 (17) | 170 |
a
Protection of neonatal mice against α-positive GBS challenge was tested.
b
Mice were immunized at days 0, 21, and 42.
c
Pups were challenged with GBS strain A909. Compared to saline, P values were as follows: *, 1; **, 0.0166; and ***, <0.0001. Compared to α2r, P values were as follows: *, 0.0003; **, 0.2573; and ***, 1.000.
d
Blood was drawn at day 60; values are geometric means for four sera.