TABLE 6.
Protection of neonatal mice from GBS infection by passive immunization with III-α2r conjugate vaccine
| Antiserum | Challenge strain | No. alive/total no. tested (% survival)a |
|---|---|---|
| III-α2r | A909 | 22/40 (55)* |
| III-α2r | M781 | 34/36 (94)** |
| Two-repeat alpha C protein (positive control) | A909 | 35/48 (73)*** |
| III-TT (positive control) | M781 | 41/42 (98)**** |
| Preimmunization (negative control) | A909 | 5/35 (19) |
| Preimmunization (negative control) | M781 | 3/47 (8) |
a
Significant differences in protection levels for different antisera were identified by Fisher’s exact test. Compared to preimmune antiserum after challenge with strain A909, P values were as follows: *, 0.0003; ***, <0.0001. Compared to preimmune antiserum after challenge with strain M781, P values were as follows: **, 0.0004; ****, <0.00001.