Table 4.
List of PA bioepitope-related gene names, PAO1 numbers, molecular weights, positions in PAO1, lengths and functions (http://pseudomonas.com)
| Gene | PAO1 Gene number | molecular weight (kDa) | location | length (bp) | function | reference |
|---|---|---|---|---|---|---|
| algU | PA0762 | 22.2 | 831,301..831882 ( +) | 582 | Regulates genes and affects a variety of physiological processes such as polysaccharide synthesis | [177] |
| lasR | PA1430 | 26.6 | 1,558,171..1558890 ( +) | 720 | quorum sensing induction regulator, regulates genes related to bioepithelial membrane formation | [178] |
| rhlR | PA3477 | 27.6 | 3,889,925..3890650 (-) | 726 | quorum sensing induction regulator, synergistic with lasR | [178] |
| bfmR | PA4101 | 28 | 4,585,149..4585889 ( +) | 741 | Regulation of extracellular polysaccharide synthesis and biofilm formation | |
| pelA | PA3064 | 104.9 | 3,431,045..3433891 (-) | 2847 | Involved in the synthesis of the extracellular polysaccharide Pel | [179] |
| pelB | PA3063 | 135.1 | 3,427,486..3431067 (-) | 3582 | / | |
| pelC | PA3062 | 18.7 | 3,426,928..3427446 (-) | 519 | / | |
| pslA | PA2231 | 54.8 | 2,453,667..2455103 (+) | 1437 | Involved in the synthesis of the extracellular polysaccharide Psl, which affects the stability of biological periplasmic membranes | [180] |
| pslB | PA2232 | 53.5 | 2,455,103..2456569 (+) | 1467 | / | |
| pslC | PA2233 | 33.6 | 2,456,569..2457480 (+) | 912 | / | |
| algD | PA3540 | 47.6 | 3,962,825..3964135 (+) | 1311 | Enzymes in the extracellular polysaccharide alginate synthesis pathway | [181] |
| algT | PA0762 | 22.2 | 831,301..831882 (+) | 582 | Transcription factor that regulates alginate synthesis | [182] |
| mexS | PA2491 | 36.8 | 2,806,350..2807369 (-) | 1020 | Involved in regulating the expression of multidrug efflux pumps | [136] |