Table 2.

Associations of serum SHBG levels with incident CHD among men and women followed for 12 years in the UKB.

	Quintiles of serum levels of SHBG
	Q1	Q2	Q3	Q4	Q5	P for trend
Men
SHBG, nmol/L	21.4 (18.0, 23.9)	29.9 (28.1, 31.6)	37.0 (35.2, 38.9)	45.4 (43.0, 48.1)	60.7 (55.3, 69.5)
Events/total (%)	1953/25683 (7.60)	2033/25681 (7.92)	2143/25664 (8.35)	2094/25650 (8.16)	2182/25644 (8.51)
HR (95% Cl)
Model 1	Ref.	0.91 (0.85, 0.97)	0.87 (0.82, 0.93)	0.78 (0.73, 0.83)	0.73 (0.69, 0.78)	<0.001
Model 2	Ref.	0.94 (0.88, 1.00)	0.92 (0.86, 0.98)	0.84 (0.79, 0.90)	0.81 (0.76, 0.87)	<0.001
Model 3	Ref.	0.97 (0.91, 1.04)	0.97 (0.91, 1.03)	0.91 (0.85, 0.97)	0.91 (0.85, 0.97)	0.001
Model 4	Ref.	0.96 (0.90, 1.02)	0.94 (0.88, 1.00)	0.88 (0.82, 0.94)	0.86 (0.79, 0.93)	<0.001
Women
SHBG, nmol/L	29.6 (24.2, 33.6)	43.6 (40.4, 46.6)	56.1 (52.9, 59.4)	70.8 (66.7, 75.5)	96.6 (87.5, 111.3)
Events/total (%)	1235/27 031 (4.57)	1028/27 034 (3.80)	845/27 018 (3.13)	741/27 008 (2.74)	663/27 012 (2.45)
HR (95% Cl)
Model 1	Ref.	0.83 (0.76, 0.90)	0.70 (0.65, 0.77)	0.64 (0.59, 0.70)	0.59 (0.54, 0.65)	<0.001
Model 2	Ref.	0.91 (0.83, 0.98)	0.81 (0.74, 0.88)	0.76 (0.69, 0.83)	0.72 (0.65, 0.79)	<0.001
Model 3	Ref.	0.95 (0.87, 1.03)	0.87 (0.80, 0.96)	0.84 (0.76, 0.93)	0.83 (0.75, 0.92)	<0.001
Model 4	Ref.	0.95 (0.86, 1.04)	0.89 (0.80, 0.98)	0.85 (0.76, 0.95)	0.84 (0.75, 0.94)	<0.001

Serum levels of SHBG were described as medium (IQR).

Model 1: Adjusted for age, assessment center, Townsend Deprivation Index, family history of cardiovascular diseases, smoking status, alcohol intake frequency, and physical activity level; Model 2: Model 1+prevalent diabetes, hypertension, or hyperlipidemia at baseline; Model 3: Model 2+BMI; Model 4: Model 3+TT.

Abbreviation: Q, quintile.